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English to Slovak: chemistry General field: Science Detailed field: Chemistry; Chem Sci/Eng
Source text - English Features common in various literature reports are that the gene mutations in IDH1 and IDH2 are point mutations and the mutation sites are focused on amino acids important for the enzymatic reactions or amino acids close thereto. Particularly, a mutation to substitute arginine at the 132-position (hereinafter, indicated as R132) of the IDH1 protein by another amino acid accounts for a great majority of the IDH1 gene mutations. As an example, a mutation to convert arginine at the 132-position to histidine (indicated as R132H) or a mutation to convert this arginine to cytosine (R132C), leucine (R132L), serine (R132S), glycine (R132G), valine (R132V), or the like has been found to occur frequently. In addition, cases where a mutation occurs in G97, R100, H133, A134, or the like are known. The IDH2 gene mutations are mostly mutations to convert R140 or R172 to another amino acid. For example, R140Q mutation or R172K or R172S mutation is known. A great majority of mutation cases also indicate that one of the alleles resides in a wild-type form.
Translation - Slovak Spoločným rysom génových mutácií v IDH1 a IDH2 podľa rôznych literárnych zdrojov je to, že ide o bodové mutácie a mutované sú aminokyseliny, ktoré sú dôležité pre enzýmové reakcie, alebo im blízke aminokyseliny. Medzi najbežnejšie génové mutácie v IDH1 patrí predovšetkým substitúcia arginínu v pozícii 132 (ďalej len R132) IDH1 proteínu s inou aminokyselinou. Bežné sú napríklad mutácie arginínu v pozícii 132 za histidín (označuje sa ako R132H) alebo mutácie tohto arginínu za cytozín (R132C), leucín (R132 l), serín (R132S), glycín (R132G), valín (R132V) alebo podobne. Ďalej sú známe prípady mutácií G97, R100, H133, A134. V prípade génových mutácií v IDH2 ide väčšinou o mutácie R140 alebo R172 za iné aminokyseliny. Známe sú napríklad R140Q alebo R172K, alebo R172S mutácie. Vo veľkej väčšine prípadov mutácií sa má za to, že jedna z alel je divokého typu.
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Years of experience: 8. Registered at ProZ.com: Aug 2020. Became a member: Jan 2021.
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